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What our customers ask. Overcome the challenges of right ventricle geometry to quantifiy volume and function. What we offer. The interior of the tumour was more regular, with occasional sparse branches that were smooth.
Tumour vascular systems became straightened with no branching between vessels. The present study used ultrasound contrast imaging to determine DVP parameters.
The greyscale changes of contrast-enhanced ultrasound were transformed into colour changes and displayed in a quantitative curve form. The DVP curve provided accurate results of quantitative analysis; therefore, the results were more objective. The enhancement pattern was associated with the distribution of the microvasculature of the tumour. As the microvessel density differed among the groups, enhancement was observed at different times. Ultrasound contrast agents are a type of blood pool contrast agent that enable the observation of the microcirculation The results of the present study showed that the DVP curves of all rats in the control group exhibited rapid enhancement and fast-fading performance.
In the ES group, the majority of lesions subsided, but the fading time was slower than that of the control group. In the DVP graph for the regression of tumour lesions, the extinction process curve was not uniform, which indicated that the microvessel density within the lesions differed Analysis shows that the quantitative parameters, including the peak intensity of the contrast agent in the control group, were higher than those in other treatment groups.
This observation is consistent with the direct observation by contrast-enhanced ultrasound. The results of the present study show that the changes of proportion of extinction and nonresolving are apparent for intervention with different treatment factors. Moreover, the quantitative parameters of contrast-enhanced ultrasound, obtained through the analysis of DVP curves, intuitively reflect the perfusion differences between lesions and the surrounding normal tissue.
The vascular characteristics of malignant tumours are unique Increased performance of the new blood vessels and lack of distribution regularity were observed.
The vessel walls were not complete and defects in the basement membrane pericytes were observed. Arteriovenous shunt and vascular rings in the large tumours in the surrounding and interior regions were also observed. Following the administration of antiangiogenic drugs, changes in vascular morphology and improved perfusion are the key points of observation. In early animal experiments, it was observed that the tumour inhibition rate in mice treated with Endostar and radiotherapy was significantly higher compared with that in the single-factor treatment groups.
Moreover, the inhibitory effect on angiogenesis was the most pronounced 17 — However, this contrasts with the increase in the overall tumour vascular perfusion. In the present study, the DVP curves of the treatment groups varied according to different morphological changes.
According to existing literature 20 , this result may be associated with the improvement of the tumour vascular network.
We hypothesise that although the combined treatment has the strongest effect on inhibiting the formation of blood vessels, the combined experimental factors also induce the abnormal tumour vasculature to become relatively normalised.
Combined treatment may increase effective perfusion, which normalises the disorder of the vascular network, leading to sufficient oxygen and blood flow into the tumour cells. A previous study reported that Endostar in combination with radiotherapy could improve the hypoxia of the tumor cell, and change the proangiogenic factors such as VEGF Analysis of the average tumour microvessel density and microvessel count are alternative methods for evaluating tumour neovascularisation.
However, these methods do not accurately reflect the efficacy of antiangiogenic therapy. Ultrasound contrast imaging accurately evaluates blood flow velocity, blood volume and blood flow parameters by mathematical models.
A comparative analysis of the parameters indirectly reflects the blood flow and perfusion changes in tumours in vivo. This effective method may provide more quantitative perfusion information to aid treatment selection. The present study aimed to explore the effects of an antiangiogenic therapy on tumour tissue perfusion using a low MI harmonic grey-scale contrast-enhanced method. The study produced clear images. The results enable the quantitative study of perfusion in tumour vessels and generally reflect the overall changes to the tumour during the treatment process.
The study also describes an imaging method that may be used to provide information about angiogenesis and the therapeutic effects of antiangiogenic drugs Further comparison and analysis of the results with those from transmission electron microscopy and confocal microscopy are warranted, which are likely to improve understanding of the treatment effect following treatment with radiotherapy combined with antiangiogenic drugs.
Mol Biol Rep. Biomed Eng Informatics. Huang G and Chen L: Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma. J Cancer Res Clin Oncol. Cosgrove D and Lassau N: Imaging of perfusion using ultrasound. View Article : Google Scholar. Invest Radiol. Quaia E: Assessment of tissue perfusion by contrast-enhanced ultrasound.
Eur Radiol.
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